The Industry 4.0 revolution envisions fully interconnected scenarios in the manufacturing industry to improve the efficiency, quality, and performance of the manufacturing processes. In parallel, the consolidation of 5G technology is providing substantial advances in the world of communication and information technologies. Furthermore, 5G also presents itself as a key enabler to fulfill Industry 4.0 requirements. In this article, the authors first propose a 5G-enabled architecture for Industry 4.0. Smart Networks for Industry (SN4I) is introduced, an experimental facility based on two 5G key-enabling technologies—Network Functions Virtualization (NFV) and Software-Defined Networking (SDN)—which connects the University of the Basque Country’s Aeronautics Advanced Manufacturing Center and Faculty of Engineering in Bilbao. Then, the authors present the deployment of a Wireless Sensor Network (WSN) with strong access control mechanisms into such architecture, enabling secure and flexible Industrial Internet of Things (IIoT) applications. Additionally, the authors demonstrate the implementation of a use case consisting in the monitoring of a broaching process that makes use of machine tools located in the manufacturing center, and of services from the proposed architecture. The authors finally highlight the benefits achieved regarding flexibility, efficiency, and security within the presented scenario and to the manufacturing industry overall. View Full-Text